First of all, allow me to thank you very much for your interest in our study.Our study was performed in a single center with a small group of patients, which may have created some bias in the prediction of adverse outcomes. In addition, the small size of the study population precluded a comparison of the outcomes between those who underwent PERCUTANEOUS coronary intervention) PCI) on native coronaries and those who received intervention on saphenous vein grafts (SVGs).Nevertheless, the results of our study showed that PCI on native coronaries is more desirable than PCI on SVGs because many of our major adverse cardiac event (MACE) cases were in the SVG group. ...

Special thanks are due to Dr. Fatemeh Behboudi et al. for their invaluable work on PERCUTANEOUS intervention on grafted veins as well as native coronary arteries in patients with previous history of coronary artery bypass graft) CABG) surgery. They report 71 patients with a history of CABG, in whom PERCUTANEOUS coronary intervention (PCI) was performed on native vessels in 60%, on grafted vessels in 32%, and on both in the remaining 8%. ...

Background: Long lesions & diffuse coronary disease present considerable challenges to the interventional cardiologist. Compared with discrete stenosis, PERCUTANEOUS REVASCULARIZATION of long lesions is associated with decreased rates; of procedural success and increased incidence of acute complications, and a propensity toward restenosis. This study was done with the aim of evaluating early & late results of PCI (PERCUTANEOUS Coronary Intervention) of long coronary lesions.Materials and Methods: In this study all of the patients (60 cases) undergone long lesion (>l5mm) PCI in the catheterization department of Imam Khomeini hospital (Tehran) at year 1382 were evaluated for occurrence of early & late complications of PCI.Results and Conclusions: In accordance with early results, 2 cases of abrupt] closure & one case of per procedural MI was detected. In long term follow up (mean 10.8m) 24.6% of patients developed restenosis on the basis of clinical manifestations, exercise treadmill test, myocardial perfusion scan and coronary angiography.Occurrence of restenosis was related to lesion length & was higher in diabetic' patients.

PERCUTANEOUS vertebroplasty is a promising therapeutic technique for pain control in patients with pathologic fractures of vertebral bodies. PERCUTANEOUS vertebroplasty is an appropriate treatment for vertebral pathologic fractures, which is resistant to other usual treatment. It is a useful and only choice in special cases, because of less tissue damage and there is no risk of open surgery and patient's embolization is rapid. Herein we described the first case of PERCUTANEOUS vertebroplasty in Yazd shahid sadoughi teaching hospital, which was done in ordybehesht 1386 in a 72 years old male with pathologic fracture of 2 lumbar vertebrae. He was suffered from pain and disability and open surgery was not appropriate treatment for him.

Introduction: Slow flow/no reflow (SF/NR) phenomenon during emergency PERCUTANEOUS REVASCULARIZATION is a feared complication associated with increased risk of adverse outcomes. CHA2DS2-VASc score has been proposed for the risk stratification but a very limited evidences are available regarding the accuracy of this system. Therefore, we conducted this study to assess the predictive value of CHA2DS2-VASc score for predicting SF/NR phenomenon during primary PERCUTANEOUS coronary intervention (PCI). Methods: This analytical cross-sectional study included 596 consecutive patients undergoing PCI for STEMI at a tertiary care cardiac center of Karachi, Pakistan. Baseline-VASc sore was calculated and development of SF/NR phenomenon during primary PCI was recorded. Predictive value of the score was assessed through area under the curve (AUC) of receiver operating characteristic curve analysis and sensitivity and specificity were computed. Logistic regression analysis was performed to assess the predictive strength of the score. Results: A total of 596 patients were included, mean age was 56. 28 ±,11. 44 years, and 75. 7%(451) were male. The slow/no reflow phenomenon during the procedure was observed in 36. 6%(218) of the patients. CHA2DS2-VASc ≥,2 was observed in 50. 2%(299) of the patients. The CHA2DS2-VASc score was significantly higher in SF/NR patients, 2. 06 ±,1. 25 vs. 1. 37 ±,1. 33,P<0. 001. The AUC of CHA2DS2-VASc score was 0. 652 [0. 607-0. 696], CHA2DS2-VASc ≥,2 had sensitivity and specificity of 65. 6% [58. 9% to 71. 9%] and 58. 3% [53. 6% to 63. 7%] respectively for predicting SF/NR. CHA2DS2-VASc ≥,2 was insignificant on multivariate with odds ratio of 1. 48 [0. 72-3. 04],P = 0. 283. Conclusion: CHA2DS2-VASc risk stratification system has moderate discriminating power for the stratification of SF/NR phenomenon during primary PCI.

A number of patients with severe obstruction due to hypertrophic cardiomyopathy have derived benefit at least over the short-term from inventional infarction of a portion of the interventricular septum by the infusion of alcohol into a selectively catheterized septal artery, with reduction of the outflow gradient and improvement in symptoms. This paper contains successful TASH on a symptomatic patient with high LVOT gradient and methods and complications.

INTRODUCTION: The generation of reactive oxygen species, which is induced by the activation of the xanthine oxidase (XO) enzymatic system, is one of the primary causes of ischemia-reperfusion injury for an ischemic heart. Allopurinol, as an XO inhibitor, plays an inhibitory role in free radical production in ST-elevation myocardial infarction (STEMI) patients. The aim of this study is to evaluate the impact of allopurinol pre-treatment on post-REVASCULARIZATION outcomes in patients admitted with STEMIMETHOD: Ninety patients with acute STEMI were enrolled in this randomized double-blind clinical trial and divided into two equal groups. The allopurinol group received a 600 mg allopurinol loading dose before the emergency PCI, and the control group received a placebo medication of the same shape. Thrombolysis in Myocardial Infarction (TIMI) flow, ECG changes, troponin level, and the occurrence of major cardiac events (MACE) during a 1-month follow-up were assessed.RESULTS: In the end, 81 patients were analyzed. The mean age of the patients was 59.52(11.31) and 61.3(9.25) in the allopurinol and control groups, respectively (p = 0.49). The troponin level 48 hours after the PCI and ST-elevation regression showed no significant difference between the groups [(p = 0.25) and (p = 0.21), respectively]. TIMI flow had improved in the allopurinol group compared to the placebo (p = 0.02). The PCI success rate was 78.6% and 61.5% in the case and control groups, respectively (p = 0.09). MACE and other clinical outcomes were similar between the groups (p > 0.05).CONCLUSION: This study revealed that allopurinol pre-treatment could improve TIMI flow in patients undergoing primary or rescue PCI in an acute STEMI setting.

Carotid stenosis is seen in about 10% of patients with ischemic stroke. Many studies have been performed that provide insight into the natural history, diagnosis, and optimal management of carotid disease. Both medical management and surgery have advanced to the point that patients and their providers have many options when considering treatment. Over the last several years, carotid artery stenting has been shown to be a viable treatment choice in selected patients. Both stenting and endarterectomy are superior to medical management alone in stroke prevention when patients are properly selected. In this article we try to review the most recent data regarding the two procedures in the treatment of carotid stenosis and also discuss the controversies in carotid artery REVASCULARIZATION.

Background: Despite recent improvement in coronary intervention, there are many controversies about its results in diabetic patients. The goal of this study is comparison of in hospital outcome of diabetics after coronary intervention with nondiabetics.Methods: In this study 115 diabetic and 115non diabetic patients who admitted for coronary intervention in our center during 1383&84 were entered in an analytic study of Cohort type. Datas about clinical, aniographic, procedural and post procedural (24hours) characteristics were entered in each patient’s form. Independent T test,chi-square and Fisher’s exact test were used for analyzing datas.Results: The Diabetic Patients were most often older men, and they had higher angina class, more co-risk factors and lower ejection fractions. Diabetic’s lesions were longer and more located in proximal portion of vessels. But success rate, major complication (death, REVASCULARIZATION, Q Wave MI and CVA), and minor complications (coronary/peripheral arteries complication, pulmonary edema, ischemic ECG) had no significant differences between two groups.Conclusion: Diabetes mellitus does not affect short outcomes of coronary intervention as an independent factor. So intervention could be done in these patients with considering favorable outcomes.

Background: Diabetes mellitus is a life threatening disease accompanied by several microand macro vascular complications. Several modalities are available for interventional REVASCULARIZATION of coronary artery lesions, but their efficacy in diabetic patients is studied only in few patients.Materials and Method: This study evaluated major in- hospital complications and clinical outcome after one year in 200 consecutive patients who underwent PERCUTANEOUS Coronary Intervention from 2007 to 2009.Results: Our findings showed comparable single and 2 vessel stenting, regarding major adverse cardiovascular event in diabetic and nondiabetic patients. In connection with long term and in hospital outcome, no statistically significant difference was found between one and two vessel stenting when drug eluting stent was used in diabetic patients.Conclusion: The use of drug eluting stent in single or two vessel disease of diabetic patients is technically satisfactory and clinically safe and can substitute for coronary artery bypass grafting.